A Molecular Mechanism for Turning off IRE1α Signaling During Endoplasmic Reticulum Stress
X. Li, S. Sun, S. Appathurai, A. Sundaram, R. Plumb, M. Mariappan
The paper identifies Sec63 as a regulator of IRE1α signaling attenuation during ER stress by recruiting BiP to inhibit IRE1 oligomerization and RNase activity.
bioRxiv · Apr 3, 2020Cell Biology