S. Sun

A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer

This study identifies TROP2 as a regulator of tight junction-mediated immune exclusion in TNBC, showing that targeting TROP2 enhances anti-PD1 therapy response.

The impact of transplant location on the gut microbiome and resistome in patients undergoing hematopoietic stem cell transplantation at home versus in the hospital

This study compares the gut microbiome and resistome of patients undergoing home versus hospital hematopoietic stem cell transplantation, finding no significant differences but noting confounding factors in secondary analyses.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Phase separated liquid vimentin droplets stabilize actin fibers through wetting

This study shows vimentin forms liquid droplets that stabilize actin fibers by wetting them, and this behavior is observed in both a mutant and wild-type vimentin.

Nitazoxanide ameliorates OVA-induced airway inflammation in asthmatic mice via p38-MAPK/ NFκB and AMPK/STAT3 pathways

This study shows nitazoxanide reduces airway inflammation in asthmatic mice by inhibiting NFκB/MAPK and AMPK/STAT3 pathways.

Cell-Driven Fluid Dynamics: A Physical Model of Active Systemic Circulation

The paper develops a mathematical model that integrates pressure and osmolarity gradients in systemic circulation, showing how cell properties influence transport and vice versa.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

A birds-eye view: exploration of the flavin-containing monooxygenase (FMO) superfamily in common wheat.

The paper catalogs FMO genes in vascular plants, focusing on wheat, and identifies their roles in disease resistance and stress responses.

A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan

This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.

Soil viruses reduce greenhouse gas emissions and promote microbial necromass accrual

This study shows soil viruses reduce greenhouse gas emissions and increase microbial necromass, influencing soil carbon storage through viral-mediated microbial mortality.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Temporal variability in host availability alters the outcome of competition between two parasitoid species

This study shows that temporal variability in host availability affects competition outcomes between two parasitoid species based on their reproductive strategies.

Mouse Adaptation of Human Inflammatory Bowel Diseases Microbiota Enhances Colonization Efficiency and Alters Microbiome Aggressiveness Depending on Recipient Colonic Inflammatory Environment

This study shows that adapting human IBD microbiota for mice improves colonization efficiency and alters microbiome aggressiveness based on the recipient's inflammatory environment.

Giardia Antagonizes Beneficial Functions of Indigenous and Therapeutic Intestinal Bacteria during Malnutrition

This study shows Giardia reduces the beneficial effects of Lactobacillus in malnourished mice, altering microbial balance and increasing intestinal damage.

Discovery of Mycodnaviridae, a clade of giant viruses that persistently infect zoosporic fungi

The paper discovers a new family of giant viruses, Mycodnaviridae, that infect zoosporic fungi and persistently infect them, expanding the known host range of Nucleocytoviricota.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

In situ structural determination of cyanobacterial phycobilisome-PSII supercomplex by STAgSPA strategy

The paper develops a method called STAgSPA to determine the in situ structure of a cyanobacterial PBS-PSII supercomplex at 3.5 Å resolution, revealing energy transfer mechanisms and structural coupling.

Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions

This study identifies a third interaction between Myo5a and Mlph, involving the exon-G region of Myo5a and Mlph-ABD, which is required for melanosome association.

A human pluripotent stem cell-based somitogenesis model using microfluidics

This study develops a microfluidic hPSC-based model to control biochemical and biomechanical signals during somitogenesis, revealing their roles in somite formation.

Immunotherapy for ovarian cancer is improved by tumor targeted delivery of a neoantigen surrogate

This study shows that delivering a neoantigen surrogate via Listeria monocytogenes combined with gemcitabine and anti-PD1 improves ovarian cancer treatment in mice.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Using a function-first "scout fragment"-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

The paper develops covalent inhibitors for conformationally dynamic helicases using electrophilic scout fragments and a function-first approach, targeting SARS-CoV-2 nsp13 and human helicases BLM and WRN.

Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells

This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.

GENOMES UNCOUPLED1: an RNA-binding protein required for early PSII biogenesis

This study identifies psbD BLRP as a target RNA of GUN1, an RNA-binding protein essential for early PSII biogenesis during seedling development.

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity

This study shows sodium chloride enhances CD8+ T-cell metabolic fitness and cytotoxicity, improving tumor cell killing in vitro and in vivo.

Evolutionary prediction for new echolocators

The paper predicts three new mammalian echolocators using molecular convergence analyses and machine learning, with behavioral experiments confirming echolocation in shrew moles.

Nitrate-driven anaerobic oxidation of ethane and butane by bacteria

This study demonstrates nitrate-dependent anaerobic oxidation of ethane and butane by Candidatus Alkanivorans nitratireducens, revealing the fumarate addition pathway's role in SCGA metabolism.

Duhuo Jisheng Decoction Regulates Intracellular Zinc Homeostasis by Enhancing Autophagy via PTEN/Akt/mTOR to Improve Knee Cartilage Degeneration

This study investigates how Duhuo Jisheng Decoction protects cartilage by enhancing autophagy through the PTEN/Akt/mTOR pathway and regulating zinc homeostasis.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

This study shows that SMARCA4 mutations in ovarian cancer increase immunogenicity through interferon response and epigenetic changes, enhancing T cell and NK cell activity in the tumor microenvironment.