M. Mariappan

Nascent Chain Ubiquitination is Uncoupled from Degradation to Enable Protein Maturation

The paper shows that ubiquitination of nascent proteins by LTN1 is reversed by deubiquitinases, allowing maturation of correctly folded proteins while misfolded ones are degraded.

Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using In vitro Platform for Improving Insulin Therapy

The paper develops a method to quantify first and second phase insulin secretion dynamics using an insulin-nanoluc luciferase reporter system, validated through genetic and small-molecule screening.

Signal Sequences Encode Information for Protein Folding in the Endoplasmic Reticulum

The paper shows signal sequences regulate protein translocation and folding in the ER by pausing translocation until chaperones bind, ensuring proper folding and preventing aggregation.

A Molecular Mechanism for Turning off IRE1α Signaling During Endoplasmic Reticulum Stress

The paper identifies Sec63 as a regulator of IRE1α signaling attenuation during ER stress by recruiting BiP to inhibit IRE1 oligomerization and RNase activity.

The C-terminal tail guides assembly and degradation of membrane proteins

This study identifies the role of C-terminal tails in guiding the assembly and degradation of membrane proteins in the ER.