Microtubule forces drive nuclear damage in LMNA cardiomyopathy
D. Amiad Pavlov, J. Heffler, C. S. Corredera, M. Dehghany, K. M. Shen, N. Zuela-Sopilniak, R. Randell, K. Uchida, R. Jain, V. Shenoy, J. Lammerding, B. L. Prosser
This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.
bioRxiv · Feb 10, 2024 · PreprintCell Biology