R. Jain

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

A Machine Learning-based approach for Simultaneous Electrochemical Detection of Interfering Analytes

This paper develops a machine learning approach to improve the accuracy of simultaneous electrochemical detection of interfering analytes by reducing prediction error.

Expression of Plasmodium Major Facilitator Superfamily Protein in Transporters-Delta Candida Identifies a Drug Transporter

The paper assesses the functional relevance of a Plasmodium MFS protein as a drug transporter using Candida glabrata, showing antifungal resistance and antimalarial properties.

Microtubule forces drive nuclear damage in LMNA cardiomyopathy

This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.

Tyrosine-sulfated peptide hormone induces flavonol biosynthesis to control elongation and differentiation in Arabidopsis primary root.

This study shows that the peptide hormone PSY1 promotes root growth by inducing flavonol biosynthesis, which regulates cell elongation and differentiation in Arabidopsis.

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

Fatty Acid Metabolism and The Oxidative Stress Response Support Bacterial Predation

This study identifies genetic and metabolic adaptations in Myxococcus xanthus that enhance bacterial predation by activating fatty acid metabolism and antioxidant responses.

A novel method of testing the antimicrobial potentials of Exiguobacterium aurantiacum, Lysinibacillus boronitolerans and Bacillus megaterium

The paper introduces a simplified one-step extraction and diffusion assay to test the antimicrobial potential of three bacterial species against human pathogens.

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

A multiadjuvant polysaccharide-amino acid-lipid (PAL) subunit nanovaccine generates robust systemic and lung-specific mucosal immune responses against SARS-CoV-2 in mice

This study develops a mucosal nanovaccine that enhances both systemic and lung-specific immunity against SARS-CoV-2 in mice through intranasal and intramuscular delivery.

Tackling emerging artemisinin resistance by modulating the defensive oxido-reductive mechanism of human malaria parasite by repurposing nitrofurantoin

This paper evaluates the anti-malarial potential of Nitrofurantoin against sensitive and resistant Plasmodium falciparum strains, finding synergistic effects with artemisinin and enhanced oxidative stress.

Identification of merozoite secreted repertoire and immuno-pharmacological inhibition of a novel host-parasite interaction to block malarial infection

This study identifies the secretory repertoire of Plasmodium merozoites and discovers a peptide that disrupts a key host-parasite interaction, blocking malarial infection.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors

This study evaluates novel CQTrICh-analogs as antimalarials, showing they inhibit Plasmodium falciparum strains and target PfCDPK1 kinase with selectivity over human kinases.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

An open source plant kinase chemogenomics set

The paper presents a plant kinase chemogenomics set, identifying compounds that affect root development in Arabidopsis and rice, with implications for understanding plant kinase function.

Protective efficacy of COVAXIN(R) against Delta and Omicron variants in hamster model

This study evaluates COVAXIN's protective efficacy against Delta and Omicron variants in hamsters, showing improved protection with a third dose and reduced disease severity.

Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV Pathogen Box

The paper identifies potent antimalarial compounds targeting PfTubulin that show multistage activity and transmission-blocking effects against Plasmodium falciparum.

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

This study shows that nanoparticle-delivered TLR4 and RIG-I agonists enhance immune responses to a SARS-CoV-2 subunit vaccine in mice, with route-specific effects on T and B cell responses.

Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of Concern

This study evaluates the pathogenicity of SARS-CoV-2 Omicron BA.1 in Syrian hamsters and finds reduced cross-neutralization against other variants.

Systematic assessment of lipid profiles for the discovery of tissue contributors to the circulating lipid pool in cold exposure

The paper uses lipidomics and computational analysis to identify tissues contributing to plasma lipid pools during cold exposure, finding the kidney and intestine as novel contributors to acylcarnitines and BAT and kidney as regulators of ceramides.

A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

The paper identifies a CD115- macrophage precursor in adult bone marrow that shares features with embryonic erythro-myeloid progenitors and is present at the maternal-embryonic interface.

Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

This study identifies a new type IV filament-like machinery, Kil, involved in contact-dependent prey killing by Myxococcus xanthus, showing its role in motility arrest and prey cell plasmolysis.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

Phosphorylation Dependent Assembly of a 14-3-3 Mediated Signaling Complex During Red Blood Cell Invasion by Plasmodium falciparum Merozoites