Conformational catalysis of cataract-associated aggregation in a human eye lens crystallin occurs via interface stealing.
E. Serebryany, W. M. Jacobs, R. Razban, E. Shakhnovich
This study reveals that wild-type HγD accelerates aggregation of the cataract-related W42Q variant through a mechanism called interface stealing, where intermolecular domain interactions outcompete native intramolecular stabilization.
bioRxiv · Apr 29, 2019 · PreprintBiophysics