J.-M. Choi

Hidden route of protein damage through confined oxygen gas

The paper identifies a hidden oxidative damage pathway in proteins through O2 confinement and photoexcitation, bypassing antioxidant defenses.

Biomolecular condensates form spatially inhomogeneous network fluids

This study uses multiple techniques to characterize the structural properties of biomolecular condensates, revealing network fluid behavior with spatial inhomogeneities.

Bystander memory-phenotype conventional CD4+ T cells exacerbating autoimmune neuroinflammation

The paper identifies bystander memory-phenotype CD4+ T cells that contribute to autoimmune neuroinflammation through TCR-independent effector functions and GM-CSF production.

LASSI: A lattice model for simulating phase transitions of multivalent proteins

LASSI simulates phase transitions of multivalent proteins using a lattice model, generating insights into condensate formation and design.

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

The paper measures NDC80 binding to microtubules in living cells and finds it is regulated by centromere tension and phosphorylation of Hec1.

ProteomeVis: a web app for exploration of protein properties from structure to sequence evolution across organisms’ proteomes

ProteomeVis explores protein evolution across S. cerevisiae and E. coli proteomes by analyzing structure, sequence, and organismal properties.

Tuning the course of evolution on the biophysical fitness landscape of an RNA virus

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.

The role of evolutionary selection in the dynamics of protein structure evolution

The paper shows that evolutionary selection for folding stability maintains protein structure despite sequence divergence, but allows rare structural innovations over longer timescales.