Branched-chain amino acid catabolism depends on GRXS15 through mitochondrial lipoyl cofactor homeostasis
A. Moseler, I. Kruse, A. E. Maclean, L. Pedroletti, S. Wagner, R. Wehler, K. Fischer-Schrader, G. Poschet, M. Wirtz, P. Dörmann, T. M. Hildebrandt, R. Hell, M. Schwarzländer, J. Balk, A. J. Meyer
The paper shows that GRXS15 deficiency disrupts mitochondrial lipoyl cofactor homeostasis, leading to metabolic defects in lipoyl cofactor-dependent dehydrogenase complexes, particularly affecting branched-chain amino acid catabolism.
bioRxiv · Feb 13, 2020 · PreprintPlant Biology