R. Hell

A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens

The paper introduces a single-sample workflow, MTBE-SP3, for simultaneous proteomic and metabolomic analysis, showing it reduces technical variation and enables consistent results across biological matrices.

Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide

The paper shows that altered iron-sulfur cluster transfer in Arabidopsis mitochondria leads to toxic sulfide release by lipoyl synthase, affecting plant growth and sulfide homeostasis.

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

Deep metabolic profiling assessment of tissue extraction protocols for three model organisms

The paper evaluates extraction protocols for metabolomic profiling in three model organisms, finding a protocol that balances reproducibility and metabolite detection across tissues.

Branched-chain amino acid catabolism depends on GRXS15 through mitochondrial lipoyl cofactor homeostasis

The paper shows that GRXS15 deficiency disrupts mitochondrial lipoyl cofactor homeostasis, leading to metabolic defects in lipoyl cofactor-dependent dehydrogenase complexes, particularly affecting branched-chain amino acid catabolism.

Redox-mediated Kick-Start of Mitochondrial Energy Metabolism drives Resource-efficient Seed Germination

The paper identifies redox-mediated activation of mitochondrial energy metabolism as critical for efficient seed germination in Arabidopsis.

Staphylococcus aureus uses the bacilliredoxin (BrxAB)/bacillithiol disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections

This study identifies the BrxAB/BSH/YpdA pathway as critical for S. aureus to manage oxidative stress and survive infections by maintaining BSH redox homeostasis.

Arabidopsis glutathione reductase 2 is indispensable in plastids, while mitochondrial glutathione is safeguarded by additional reduction and transport systems

The paper investigates the role of GR2 in maintaining glutathione redox homeostasis in plastids and mitochondria of Arabidopsis, showing its essential function in plastids and partial redundancy in mitochondria.

Pyrophosphate modulates stress responses via SUMOylation

This study shows that pyrophosphate modulates stress responses by inhibiting SUMOylation, affecting cold and heat stress sensitivity in plants and yeast.