Author

R. Witte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

U. F. Greber· 5 shared A. Yakimovich· 4 shared F. Georgi· 4 shared V. Andriasyan· 4 shared F. Kuttler· 2 shared G. Turcatti· 2 shared L. Murer· 2 shared A. Gaudin· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

U. F. Greber

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

R. Ojha, A. Jiang, E. Mantyla, N. Modhiran, R. Witte, A. Gaudin, L. De Zanetti, R. Gormal, M. Vihinen-Ranta, J. Mercer, M. Suomalainen, U. F. Greber, Y. Yamauchi, P. Yves-Lozach, A. Helenius, , G. Balistreri

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

bioRxiv · Jul 2, 2023 · PreprintMicrobiology

The FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of human adenoviruses

F. Georgi, V. Andriasyan, R. Witte, L. Murer, S. Hemmi, L. Yu, M. Grove, N. Meili, F. Kuttler, A. Yakimovich, G. Turcatti, U. F. Greber

This paper shows that the FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of certain human adenoviruses but not non-lytic transmission.

bioRxiv · May 15, 2020Microbiology

High-content image-based drug screen identifies a clinical compound against cell transmission of adenovirus

F. Georgi, F. Kuttler, L. Murer, V. Andriasyan, R. Witte, A. Yakimovich, G. Turcatti, U. F. Greber

The paper identifies Nelfinavir mesylate as an inhibitor of adenovirus multi-round plaque formation using an image-based high-throughput screening platform.

bioRxiv · Mar 24, 2020Microbiology

Deep learning of virus infections reveals mechanics of lytic cells

V. Andriasyan, A. Yakimovich, F. Georgi, A. Petkidis, R. Witte, D. Puntener, U. F. Greber

The paper uses deep learning to predict lytic and nonlytic virus infections from imaging data, identifying key phenotypic differences 20 hours before lysis.

bioRxiv · Oct 9, 2019 · PreprintCell Biology

Label-free digital holo-tomographic microscopy reveals virus-induced cytopathic effects in live cells

A. Yakimovich, R. Witte, V. Andriasyan, F. Georgi, U. F. Greber

This study introduces digital holo-tomographic microscopy to observe virus-induced cytopathic effects in live cells with minimal phototoxicity and reveals virus-specific changes.

bioRxiv · Aug 29, 2018Cell Biology