A. Jiang

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment

This study shows that dual FGFR/VEGFR inhibition causes regression of acral melanoma by targeting the tumor microenvironment rather than directly killing cancer cells.

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases

This study demonstrates that DNA origami vaccine nanoparticles enhance both humoral and cellular immune responses against infectious diseases like SARS-CoV-2, HIV, and Ebola.

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

Single cell spatial analysis and biomarker discovery in Hodgkin lymphoma

This study uses spatial imaging to analyze Hodgkin lymphoma tumor microenvironments and identifies new biomarkers related to immune cell interactions and checkpoints.

The spatially resolved tumor microenvironment predicts treatment outcome in relapsed/refractory Hodgkin lymphoma

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer

This study shows estrogen therapy induces DNA damage in ER+ breast cancer cells, which can be enhanced by PARP inhibition to improve treatment outcomes.

Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2

The paper uses AlphaFold2 to identify and validate interactions of Mint proteins with Munc18-1 and their broader interactome, revealing structural and functional insights into neuronal membrane trafficking.

Hemoxygenase-1 as a key mediator of acute radiation pneumonitis revealed in a human lung alveolus-on-a-chip

This study uses a human lung alveolus-on-a-chip to show that HMOX-1 mediates acute radiation-induced lung injury and that its activation reduces early injury but worsens later damage.

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

The paper uses patient-derived iPSC-CMs and optical biosensors to profile signaling changes in idiopathic dilated cardiomyopathy, aiming to uncover personalized disease mechanisms and therapeutic targets.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

MOLECULAR VIDEOGAMING: SUPER-RESOLVED TRAJECTORY-BASED NANOCLUSTERING ANALYSIS USING SPATIO-TEMPORAL INDEXING

The paper introduces a new method to analyze SMLM data by incorporating temporal information, revealing transient nanoclusters of syntaxin1a and Munc18-1 on the plasma membrane.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip

This study shows that mechanical breathing motions suppress viral replication by enhancing innate immune responses in a human Lung Alveolus Chip model.

The PIF1-MIR408-Plantacyanin Repression Cascade Regulates Light Dependent Seed Germination

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Human bone marrow disorders recapitulated in vitro using organ chip technology

The paper describes a Bone Marrow-on-a-Chip model that mimics bone marrow function and disease states, including drug and radiation responses and Shwachman-Diamond Syndrome abnormalities.