Allelic DNA synthesis followed by template switching underlies BRCA1-linked tandem duplication
Z.-C. Huang, Y.-L. Feng, Q. Liu, R.-D. Chen, S.-C. Liu, M. Wang, A.-Y. Xie
The paper investigates BRCA1-linked tandem duplication formation in Brca1-deficient cells and identifies allelic DNA synthesis and template switching as key mechanisms.
bioRxiv · Feb 20, 2024Cancer Biology