Q. Liu

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer's disease

This paper identifies Sarm1 as a driver of synapse degeneration and memory loss in Alzheimer's disease by showing its deletion prevents synapse loss and cognitive decline in mouse models.

Modifications to the gut microbiome alter bone matrix proteomics and fracture toughness at the cellular scale

This paper shows that altering the gut microbiome changes bone matrix proteomics and reduces fracture toughness, with micropillar splitting as a precise method to measure these effects.

Dimorphic Neural Network Architecture Prioritizes Sexual-related Behaviors in Male C.elegans

The paper analyzes neural network architectures in male and hermaphrodite C. elegans to identify how sexual-specific neurons influence dimorphic behaviors.

A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

The paper identifies a Pseudomonas aeruginosa VgrG2b fragment cleaved by caspase-11 that inhibits NLRP3 inflammasome activation, promoting infection and improving survival with a specific peptide inhibitor.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Embracing Uncertainty Reshapes the ETHYLENE INSENSITIVE2-Activated Ethylene Signaling Framework

The paper challenges the current model of ethylene signaling by showing EIN2 activation can occur independently of CTR1, ETP1/ETP2, and MHL1/MHL2, and reveals new interactions and regulatory mechanisms.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

FOXP3+ Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza Infection

This study shows that FOXP3+ Treg cells use TBET to control activated CD8+ T cells during influenza recovery, but not Trm cell generation.

Conserved mycobacterial sRNA B11 regulates lipooligosaccharide synthesis at post-transcriptional level

This study identifies B11, a conserved mycobacterial sRNA, as a post-transcriptional regulator of lipooligosaccharide synthesis, revealing its mechanism of action through RNA-seq and mass spectrometry.

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function

This study identifies msiCAT-tailing of mitochondrial proteins as a mechanism promoting glioblastoma growth by enhancing mitochondrial function and reducing apoptosis.

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

Diversity and ecological potentials of viral assemblages from the seamount sediments of the Northwest Pacific Ocean

The paper analyzes viral diversity in seamount sediments, identifying 78,069 vOTUs and 16 vAMGs, suggesting ecological roles in biogeochemical cycles.

Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

SwinCell: a transformer-based framework for dense 3D cellular segmentation

SwinCell is a 3D transformer-based framework that improves segmentation of dense cellular images by balancing local feature recognition and contextual understanding.

de Novo Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 Vaccination

This paper presents a method to sequence polyclonal IgG antibodies from human plasma post-SARS-CoV-2 vaccination, generating recombinant antibodies with neutralizing capabilities.

eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculation

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

Effect of Electroacupuncture Pretreatment on Cognitive Impairment and Mitophagy in Aging Model Rats and its mechanism

This study investigates how electroacupuncture pretreatment affects cognitive impairment and mitophagy in aging rats, finding it improves cognitive function by enhancing mitophagy and mitochondrial function.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA

The paper identifies Schlafen-11 and -9 as innate immune sensors that recognize intracellular single-stranded DNA containing CGT motifs, leading to cytokine expression and cell death.

Allelic DNA synthesis followed by template switching underlies BRCA1-linked tandem duplication

The paper investigates BRCA1-linked tandem duplication formation in Brca1-deficient cells and identifies allelic DNA synthesis and template switching as key mechanisms.

Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

This study shows thyroid hormone promotes differentiation of medulloblastoma cells, reducing tumor growth by reversing EZH2-mediated repression of NeuroD1.

Cell circuits underlying nanomaterial specific respiratory toxicology

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms.

This study uses single-molecule microscopy to show NiV-F forms nanoclusters on membranes, which promote fusion by enabling interactions with the NiV-G/receptor complex.

PerturBase: a comprehensive database for single-cell perturbation data analysis and visualization

PerturBase is a database that compiles and visualizes single-cell perturbation data from multiple studies, enabling analysis of genetic and chemical perturbations across millions of cells.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

miR-100 and miR-125b Contribute to Enhanced 3D Growth and Invasiveness and can be Functionally Transferred to Silence Target Genes in Recipient Cells

This study identifies miR-100 and miR-125b as regulators of 3D growth and invasiveness in cancer cells, showing they can be transferred extracellularly to silence target genes in recipient cells.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk

The paper identifies seven thymic conventional dendritic cell subsets and their distinct functional roles and dependencies on thymocyte subsets for homeostasis and activation.