ER stress-associated IRE1α signalling links impaired QPRT-dependent NAD⁺ biosynthesis to reduced oocyte competence
Mohd Athar, Ajith Kumar E, Pravin Birajdar, Rajender M, Akshay Kumar, Anjali Kumari, Sahina Sabnam, Ankita Verma, Pradnya. L, Partha Sarathi Nial, Taru Sharma G, HBD Prasada Rao
This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.
bioRxiv · Nov 6, 2026 · PreprintCell Biology