Scorpion toxin peptide BMK86-P1 achieves mutation-reversible inhibition of KCNA2 at the cost of reduced efficacy in heteromers and murine neurons
Elisabeth M.M. Brand, Lorenz Over, Hubert Kalbacher, Remy Lambert, Stefano Iavarone, Hang Lyu, Ulrike B. S. Hedrich, Peter Müller
The paper demonstrates that the scorpion toxin BMK86-P1 selectively inhibits KV1.2 homomers but not heteromers, with a mutation reducing its efficacy and altering channel activation.
bioRxiv · Sep 3, 2026 · PreprintNeuroscience