sPRR signaling in macrophages via the AT1R/Yap/Taz axis to induce renal fibrosis
Ye Feng, Huaqing Zheng, Shiying Xie, Fei Wang, Renfei Luo, Tianxin Yang
This study identifies the sPRR/AT1R/Yap/Taz axis in macrophages as a driver of renal fibrosis in UUO by promoting M2 polarization and fibrotic gene expression.
bioRxiv · Apr 7, 2026 · PreprintPathology