Author

Rick Orr

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Systems Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1 Organism:human· 1 Approach:statistical model· 1

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David C. YeomansiD· 1 shared Julien Mamet· 1 shared Michael KlukinoviD· 1 shared William K Martin· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperSystems Biology

David C. YeomansORCID

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1 paper

Recent·Most cited

Core Coefficient quantifies transcription-factor functional dominance for therapeutic target selection

Michael Klukinov, Rick Orr, William K Martin, David C. Yeomans, Julien Mamet

The paper introduces the Core Coefficient (CC) to quantify transcription factor functional dominance in regulatory networks, showing it can predict therapeutic target shifts in disease progression.

bioRxiv · Oct 28, 2026 · PreprintSystems Biology