Systems BiologybioRxivPreprint
Core Coefficient quantifies transcription-factor functional dominance for therapeutic target selection
Michael Klukinov, Rick Orr, William K Martin…·Julien Mamet
The paper introduces the Core Coefficient (CC) to quantify transcription factor functional dominance in regulatory networks, showing it can predict therapeutic target shifts in disease progression.
DOI 10.64898/2026.10.27.760230