David C. Yeomans

This study uses a transcription factor network analysis to show HOX TFs are functionally dominant in HD brains and that a HOX inhibitor improves disease phenotypes in mice.

The paper introduces the Core Coefficient (CC) to quantify transcription factor functional dominance in regulatory networks, showing it can predict therapeutic target shifts in disease progression.

This paper demonstrates that noninvasive ultrasound-guided focused ultrasound can selectively and reversibly inhibit peripheral nociceptive fibers and prevent acute pain in a rat model.

This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.