Balancing dynamic tradeoffs to drive cellular reprogramming
Kimberley N. Babos, Kate E. Galloway, Kassandra Kisler, Madison Zitting, Yichen Li, Brooke Quintino, Robert H. Chow, Berislav V. Zlokovic, Justin K. Ichida
This study identifies dynamic transcription-replication tradeoffs that limit cellular reprogramming and shows that hypertranscription and hyperproliferation enhance reprogramming efficiency.
bioRxiv · Aug 17, 2018 · PreprintCell Biology