Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness
Máté Katona, Shuai Yuan, Robert Hall, Olivier Romito, Stefanie N. Taiclet, Sydney S. Tomman, Scott A. Hahn, Katherine C. Wood, Mohamed Trebak, Adam C. Straub
This paper identifies CYB5R3 as a redox switch that couples store-operated calcium entry to TRPV2 activation, enhancing vascular function through NO-dependent oxidative inhibition of PTPN1.
bioRxiv · Oct 8, 2025 · PreprintCell Biology