Multi-dimensional optimization of a lysin towards a ribolysin against life-threatening S. aureus infections: Fc-LysM-CHAP and its strong synergy with standard of care antibiotics
Adriana Badarau, Benedikt Bauer, Zehra Visram, Renping Qiao, Andrea Majoros-Hashempour, Johannes Söllner, Svetlana Ðurica-Mitić, Orla M. Dunne, Robert Kluj, Donaat Kestemont, Ann-Katrin Kieninger, Monika Kulig, Rocío Berdaguer, Timo Schwebs, Manuel Zerbs, , Lorenzo Corsini
This paper develops an Fc-fused lysin, Fc-LysM-CHAP, optimized for improved pharmacokinetics and synergy with antibiotics against S. aureus infections.
bioRxiv · May 8, 2026 · PreprintMicrobiology