A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors
Rupesh H. Amin, Kevin G. Haworth, Howell F. Moffett, Jerry C. Chen, Lisa Park, Jason K. Yokoyama, Allan L. Wang, Leah J. Tait, Maria M. Steele, John T. Crowl, Thaddeus M. Davenport, Joseph DeSautelle, Jared Louis Hammer, Willimark Obenza, Vanessa R. Montoya, , Aaron Edward Foster
This paper designs a transgene that enhances CAR T cell persistence and tumor regression by integrating multiple engineered technologies in solid tumor models.
bioRxiv · Sep 24, 2026 · PreprintSynthetic Biology