Elucidation of Sequence Constraints for Protein Folding on the Ribosome
Rohan Bhardwaj, Caden Sillman, Charles P Kuntz, Brianna Corman, J Paul Robinson, Jonathan P Schlebach
This study investigates how ribosome-mediated protein folding imposes sequence constraints by analyzing mutations in E. coli DHFR using deep mutational scanning and fluorogenic sensors.
bioRxiv · Nov 10, 2026 · PreprintBiophysics