Author

Rui Liao

Army Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Synthetic Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Organism:mouse· 2 Assay:multiome· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Shan GuaniD· 4 shared Jingjing ZhangiD· 2 shared Joseph RoseneckeriD· 2 shared Mingxing Luo· 2 shared Qin Xiao· 2 shared Xiaoyan DingiD· 2 shared Yuheng LiuiD· 2 shared Chao Li· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersSynthetic Biology

Shan GuanORCID

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Author profile →

4 papers

Recent·Most cited

Tc17-driven antibody-independent mucosal immunity is critical for protection against extracellular bacterial pneumonia

Yuheng Liu, Jingjing Zhang, Zhifu Chen, Rui Liao, Chao Li, Qin Xiao, Shan Guan

This paper shows that mucosal mRNA vaccines protect against Kp pneumonia via Tc17 cells, not antibodies, and introduces an exosome platform enhancing vaccine efficacy.

bioRxiv · Aug 31, 2026 · PreprintImmunology

Deoxyribonucleotide incorporation reshapes mRNA design beyond canonical ribonucleotide boundaries

Xiaoyan Ding, Rui Liao, Giovana Bampi, Dandan Zhang, Shan Guan, Joseph Rosenecker

This paper shows that substituting ribonucleotides with deoxyribonucleotides in mRNA improves translation efficiency and therapeutic potential in vivo.

bioRxiv · Jul 10, 2026 · PreprintSynthetic Biology

Host Microenvironment Reprogramming by Saccharides Overcomes Lung Barriers for mRNA Therapeutics

Lifeng Xu, Tingting Chen, Chao Li, Rui Liao, Qin Xiao, Yang Chen, Fating Yang, Mingxing Luo, Mingyu Zhang, Shan Guan

This paper identifies glucose as a reprogramming agent for the airway microenvironment to enhance mRNA delivery and efficacy in lung models.

bioRxiv · Jul 14, 2025 · PreprintBioengineering

Airway applied IVT mRNA vaccine needs specific sequence design and high standard purification that removes devastating dsRNA contaminant

Jingjing Zhang, Chao Li, Yuheng Liu, Rui Liao, Dian He, Lifeng Xu, Tingting Chen, Qin Xiao, Mingxing Luo, Yang Chen, Yali Li, Huaxing Zhu, Joseph Rosenecker, Xiaoyan Ding, Shuchen Pei, Shan Guan

This study shows airway mRNA vaccines need better purification and sequence design to avoid dsRNA contaminants, leading to improved immune responses.

bioRxiv · Sep 22, 2024 · PreprintSynthetic Biology