Author

Ruth Misir

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genomics· 2

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Organism:human· 5 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:ATAC-seq· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Jaroslav M. BendliD· 5 shared John F. FullardiD· 5 shared Panos RoussosiD· 5 shared Gabriel E. HoffmaniD· 4 shared Pengfei DongiD· 4 shared Steven P. KleopoulosiD· 4 shared Vahram H. HaroutunianiD· 4 shared Biao ZengiD· 3 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Jaroslav M. BendlORCID

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5 papers

Recent·Most cited

Transcriptome and chromatin accessibility landscapes across 25 distinct human brain regions expand the susceptibility gene set for neuropsychiatric disorders

Pengfei Dong, Liting Song, Jaroslav M. Bendl, Ruth Misir, Zhiping Shao, Jonathan Edelstien, David A. Davis, Vahram H. Haroutunian, William K. Scott, Susanne Acker, Nathan Lawless, Gabriel E. Hoffman, John F. Fullard, Panos Roussos

The paper maps transcriptomic and chromatin accessibility profiles across 25 human brain regions and identifies genes linked to neuropsychiatric disorder risk.

Nature Communications · Nov 21, 2024Peer-reviewedNeuroscience

Genetic regulation of cell-type specific chromatin accessibility shapes the etiology of brain diseases

Biao Zeng, Jaroslav M. Bendl, Chengyu Deng, Donghoon Lee, Ruth Misir, Sarah M. Reach, Steven P. Kleopoulos, Pavan Kumar Auluck, Stefano Marenco, David A. Lewis, Vahram H. Haroutunian, Nadav Ahituv, John F. Fullard, Gabriel E. Hoffman, Panos Roussos

The paper identifies cell-type specific chromatin accessibility QTLs and their functional impact on brain disease risk.

Science · May 23, 2024Peer-reviewedGenomics

From compartments to gene loops: Functions of the 3D genome in the human brain

Samir Rahman, Pengfei Dong, Pasha Apontes, Michael B. Fernando, Roman Kosoy, Kayla G. Townsley, Kiran Girdhar, Jaroslav M. Bendl, Zhiping Shao, Ruth Misir, Nadejda M. Tsankova, Steven P. Kleopoulos, Kristen Brennand, John F. Fullard, Panos Roussos

This study investigates the 3D genome organization in human brain development, finding differences in compartment and loop domain formation between neurons and glia.

Nucleic Acids Research · Oct 9, 2023Peer-reviewedGenomics

The three-dimensional landscape of chromatin accessibility in Alzheimer's disease

Jaroslav M. Bendl, Mads E. Hauberg, Kiran Girdhar, Eunju Im, James M. Vicari, Samir Rahman, Michael B. Fernando, Kayla G. Townsley, Pengfei Dong, Ruth Misir, Steven P. Kleopoulos, Sarah M. Reach, Pasha Apontes, Biao Zeng, Wen Zhang, , Panos Roussos

This study maps chromatin accessibility in Alzheimer's disease using ATAC-seq, identifying regulatory changes and 3D genomic alterations linked to disease.

Nature Neuroscience · Sep 28, 2022Peer-reviewedNeuroscience

Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain

Pengfei Dong, Gabriel E. Hoffman, Pasha Apontes, Jaroslav M. Bendl, Samir Rahman, Michael B. Fernando, Biao Zeng, James M. Vicari, Wen Zhang, Kiran Girdhar, Kayla G. Townsley, Ruth Misir, Andrew J. Chess, Attila Gulyás-Kovács, Bibi S. Kassim, , Panos Roussos

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

Nature Genetics · Sep 26, 2022Peer-reviewedNeuroscience