Wen Zhang

The paper analyzes the evolutionary history and microbial interactions of Bifidobacterium longum subspecies in infants, finding that subspecies distribution is shaped by ecological factors and cross-feeding rather than host-specific factors.

This paper develops a multi-modal deep learning framework to identify Class I HDAC inhibitors as broad-spectrum anti-cancer agents by integrating chemical and transcriptomic data.

This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.

MACGA predicts lncRNA-disease associations using a graph attention network with multi-scale adaptive convolution, outperforming existing methods in cross-validation and validated by case studies.

Rprot-Vec is a deep learning model that rapidly calculates protein structural similarity and detects homology using only sequences, achieving 65.3% accuracy in homologous protein prediction.

This study generates an Fzd8-knockout mouse model using CRISPR/Cas9 to investigate its role in bone development and homeostasis, finding altered osteoclast and osteoblast activity and potential links to osteoporosis.

The paper identifies a hypothalamic circuit involving Calb1+ neurons and Pomc+ neurons that coordinates β-endorphin release with ejaculation in male mice.

This study maps chromatin accessibility in Alzheimer's disease using ATAC-seq, identifying regulatory changes and 3D genomic alterations linked to disease.

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

This study identifies 18 significant genetic loci associated with speech sound disorders through GWAS and finds polygenic risk scores linked to clinical severity.

The paper functionally annotates rare structural variants in the human brain by integrating SV calling with RNA-seq data to assess their regulatory effects and prioritize pathogenic deletions.

This study shows Kif5b interacts with clathrin heavy chain and facilitates CCV uncoating, linking anterograde transport to clathrin-mediated endocytosis.