Epigenetic Rescue of Disuse Muscle Atrophy by Histone Deacetylase Inhibitor Trichostatin A
Kanita Hrustanovic, Scott Burlingham, Katie Sikes, Ryan Foslien, Kenna Thomas, Lauren Monroe, Benjamin Gadomski, Soham Ghosh
This study shows that Trichostatin A, an HDAC inhibitor, reduces muscle atrophy and preserves nuclear organization in mice subjected to mechanical unloading.
bioRxiv · Nov 6, 2026 · PreprintPhysiology