The membrane distal domain of CD16a allosterically regulates NK cell ADCC
Tania Cid, Monica Fernandez-Quintéro, Hijab Fatima, Ema Robinson, Braden Christenson, Johannes R. Loeffler, Daniel P. Leaman, Ryan Lin, Kayla Xu, Jessica Matthias, Scott C. Henderson, Kathryn Spencer, Joseph Jardine, Michael B. Zwick, Andrew B. Ward, , Charles Daniel Murin
This paper identifies an allosteric checkpoint in CD16a that regulates NK cell ADCC independently of IgG-Fc binding, revealing a mechanism for modulating immune responses.
bioRxiv · Jul 6, 2026 · PreprintImmunology