Johannes R. Loeffler

This paper identifies an allosteric checkpoint in CD16a that regulates NK cell ADCC independently of IgG-Fc binding, revealing a mechanism for modulating immune responses.

This study determines the structural basis of antigen recognition by two mAbs targeting PfCSP, revealing conserved and distinct binding modes and their implications for antibody function.

This study designs a protein that precisely controls Gremlin-1 antagonism by releasing BMPs, revealing the role of interface rigidity in antagonist function.

This study improves HIV broadly neutralizing antibodies through multistate engineering, resulting in enhanced breadth and potency against diverse Env variants.

The paper predicts the structural flexibility of antibody and T-cell receptor CDR3 loops using a new method trained on a large dataset of conformations.

This paper uses cryoEM to analyze antibody-antigen interactions with HIV MPER-GT immunogens, revealing binding patterns and epitopes that inform antigen optimization.

This paper designs de novo pMHC binders using generative models to create T cell-based cancer therapeutics with high specificity and minimal cross-reactivity.

The paper shows that genetic variation in human immunoglobulin genes affects antibody responses to influenza HA, informing vaccine design to cover diverse populations.

This study uses MINFLUX nanoscopy to map CD16a spatial distribution in NK cells, revealing CD16a pairs and increased density at synapses during ADCC activation.

The paper identifies two human monoclonal antibodies that broadly inhibit PfEMP1's binding to EPCR, a key process in severe malaria pathogenesis.

This study evaluates AF2's ability to predict protein structural ensembles by comparing its results with MD simulations and NMR data for four test proteins.