Emily Margaret Mace

This study identifies CXCR4 and CXCL12 as regulators of stromal-NK cell interactions that control NK cell adhesion, migration, and maturation in humans.

This paper identifies an allosteric checkpoint in CD16a that regulates NK cell ADCC independently of IgG-Fc binding, revealing a mechanism for modulating immune responses.

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.

The paper identifies a CDC45 variant causing immune disease with allelic bias, linking it to NK cell dysfunction and variable expressivity in a family.

This study shows that allelic bias in GINS4 variants contributes to variable clinical and cellular phenotypes in NK cell deficiency.

The paper investigates cell-to-cell communication in Alzheimer's disease to characterize disease biology and suggest new avenues for therapeutic intervention.

This study uses MINFLUX nanoscopy to map CD16a spatial distribution in NK cells, revealing CD16a pairs and increased density at synapses during ADCC activation.

This study shows that PAG links to the actin cytoskeleton, and this interaction is essential for T cell synapse formation and cytotoxic function.

The paper examines immunosenescence trajectories in diverse populations, finding associations between immunological age and brain atrophy, while highlighting CMV status and genetic ancestry as key factors.

This study shows that replication stress in activated human NK cells increases apoptosis and impairs function, linking helicase deficiency to NK cell deficiency.

cellPLATO identifies cell behaviour in trajectory data by clustering morphology and motility metrics, revealing IL-15's role in increasing NK cell migration plasticity.

This study shows CD56/NCAM is essential for human NK cell migration by modulating actin dynamics and integrin turnover during movement on stromal cells.

This study maps human natural killer cell development in pediatric tonsil using imaging mass cytometry and high-resolution microscopy, revealing stage-specific localization and interactions.

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.

The paper introduces a quantitative model of innate immune activation regulation using Bayesian inference, revealing tradeoffs between precision and adaptation.

This study uses live-cell imaging and statistical analyses to show IQGAP1 regulates actin dynamics around endosomes through PIP3-dependent tethering and transient inhibition of actin growth.