Author

Ryuta Ishii

Shionogi (Japan)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

D. K. InaokaiD· 3 shared Takaya SakuraiD· 3 shared Teruhisa KatoiD· 3 shared Kiyoshi KitaiD· 2 shared Aiko Hattori· 1 shared Endah Dwi HartutiiD· 1 shared Eri Yoshida· 1 shared Hina Yuasa· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

D. K. InaokaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural insights and mechanistic inhibition of Plasmodium falciparum dihydroorotate dehydrogenase by newly identified chemotypes

Japheth Kibet Ng'etich, Ryuta Ishii, Hina Yuasa, Ryo Hatanaka, Aiko Hattori, Jun-ichi Kishikawa, Endah Dwi Hartuti, Normalita Eka Pravitasari, Kiyoshi Kita, Yusuke Tateno, Teruhisa Kato, Takaya Sakura, T. Shiba, D.K. Inaoka

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

bioRxiv · Oct 26, 2026 · PreprintMicrobiology

Efficient identification of antimalarials with novel mechanism of action via multi-sample transcriptomic profiling

Ryuta Ishii, Takaya Sakura, Jing Han Hong, Kazuya Yasuo, Kazunari Hattori, Paul A. Willis, Teruhisa Kato, D.K. Inaoka

This study identifies antimalarials with novel mechanisms by comparing transcriptomic changes from drug perturbations in Plasmodium falciparum.

bioRxiv · Feb 27, 2025 · PreprintMicrobiology

Accelerating antimalarial drug discovery with a new high-throughput screen for fast-killing compounds

Takaya Sakura, Ryuta Ishii, Eri Yoshida, Kiyoshi Kita, Teruhisa Kato, D. K. Inaoka

This paper introduces a high-throughput screening method to identify fast-killing antimalarial compounds by measuring parasite reduction ratio using Plasmodium falciparum lactate dehydrogenase and fluorescent probes.

ACS Infectious Diseases · Nov 19, 2024Peer-reviewedMicrobiology