Takaya Sakura

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

This study examines changes in the H3K27me3 epigenetic mark in Theileria annulata-transformed macrophages during attenuation, finding increased global H3K27me3 levels and broader genomic distribution without major transcriptional changes.

This study shows that PfDGAT is essential for Plasmodium falciparum survival by maintaining phospholipid homeostasis, regulating sexual differentiation, ER stress, and cytoadhesion.

This study identifies antimalarials with novel mechanisms by comparing transcriptomic changes from drug perturbations in Plasmodium falciparum.

This study identifies PfLPLAT1 as essential for Plasmodium falciparum cell cycle progression and cytostome function, with its deficiency causing developmental arrest and morphological changes.

This paper introduces a high-throughput screening method to identify fast-killing antimalarial compounds by measuring parasite reduction ratio using Plasmodium falciparum lactate dehydrogenase and fluorescent probes.

The paper identifies glycolytic enzyme condensates in Plasmodium falciparum under low glucose conditions, showing they form distinct structures without lipid membranes.