In vivo silencing of regulatory elements using a single AAV-CRISPRi vector
Patrick Laurette, C Cao, Deepak Prabhu Ramanujam, Martin Schwaderer, T. Lueneburg, S Kuss, L. Weiss, Ramile Dilshat, Eileen E. M. Furlong, Flávia Rezende, Stefan Hanns Engelhardt, Ralf Gilsbach
This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.
bioRxiv · Nov 5, 2023 · PreprintGenomics