Stefan Hanns Engelhardt

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

The paper develops Allelome.LINK to predict cis-acting ncRNA-targets using allele-specific expression, finding 2,291 shared events validated by eQTLs and linking 30.59% of GWAS variants to pcGene targets.

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

The paper identifies a retrograde transit filter in distal axons mediated by optineurin that regulates mitochondrial homeostasis, independent of PINK1 and parkin.

This study shows that reduced progranulin leads to increased legumain activity, which promotes TDP-43 pathology in FTLD, suggesting legumain as a therapeutic target.

This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.