GenomicsbioRxivPreprint
In vivo silencing of regulatory elements using a single AAV-CRISPRi vector
Patrick Laurette, C Cao, Deepak Prabhu Ramanujam…·Ralf Gilsbach
This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.