ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice
Y. Yamauchi, S. Abe-Dohmae, N. Iwamoto, R. Sato, S. Yokoyama
This study shows ABCA1 deficiency leads to tissue-specific SREBP2 pathway dysregulation in mice, depending on nutritional status, contributing to cholesterol deposition and atherosclerosis.
bioRxiv · Feb 20, 2024Physiology