Author

S. Agca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Kir· 3 shared S. N. Bilgic· 3 shared A. Domaniku· 2 shared B. Toledo· 2 shared A. Domaniku Waraich· 1 shared A. E. Kashgari· 1 shared A. Loumaye· 1 shared B. Z. C. Weber· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

S. Kir

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism

S. Agca, A. Domaniku Waraich, S. N. Bilgic, M. Sucuoglu, M. Dag, S. A. Dogan, S. Kir

This study examines single-nucleus transcriptomes of atrophying muscles in cachectic mice, identifying gene signatures and pathways associated with protein degradation and reduced oxidative metabolism.

bioRxiv · Oct 26, 2023Cell Biology

Activated Oncostatin M signaling drives cancer-associated skeletal muscle wasting

A. Domaniku, S. Agca, B. Toledo, S. N. Bilgic, A. E. Kashgari, S. Kir

This study shows that OSM/OSMR signaling drives cancer-associated muscle wasting and suggests targeting this pathway could prevent muscle loss.

bioRxiv · Jan 26, 2023Cancer Biology

EDA2R/NIK signaling promotes skeletal muscle atrophy linked to cancer cachexia

S. N. Bilgic, A. Domaniku, B. Toledo, S. Agca, B. Z. C. Weber, D. H. Arabaci, Z. Ozornek, P. Lause, J.-P. Thissen, A. Loumaye, S. Kir

This study identifies EDA2R/NIK signaling as a driver of cancer cachexia-induced skeletal muscle atrophy and shows that targeting this pathway can prevent muscle loss.

bioRxiv · Jan 23, 2023Cancer Biology