Cancer BiologybioRxiv
EDA2R/NIK signaling promotes skeletal muscle atrophy linked to cancer cachexia
S. N. Bilgic, A. Domaniku, B. Toledo…·S. Kir
This study identifies EDA2R/NIK signaling as a driver of cancer cachexia-induced skeletal muscle atrophy and shows that targeting this pathway can prevent muscle loss.
DOI 10.1038/s41586-023-06047-y