Inhibition of GFAT1 in lung cancer cells destabilizes PD-L1 protein and improves immune response
W. Chen, B. Saxton, S. Belinsky
This study shows that inhibiting GFAT1 reduces PD-L1 stability in lung cancer cells, enhancing immune response by boosting T cell activation and NK cell cytotoxicity.
bioRxiv · Nov 17, 2020Cancer Biology