Contact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregation
H. S. Ilamathi, S. Benhammouda, A. Lounas, K. Al-Naemi, J. Desrochers-Goyette, M. A. Lines, F. Richard, J. Vogel, M. Germain
The paper shows that ER sheet-mitochondria contact sites regulate mtDNA replication and distribution, with DRP1 loss disrupting this interaction and causing mtDNA issues.
bioRxiv · Dec 9, 2021Cell Biology