P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity
F. Gasparri, D. Sarkar, S. Bielickaite, M. H. Poulsen, A. Hauser, S. A. Pless
This study maps missense variants in P2X2 receptor inter-subunit interfaces and shows mutations often increase apparent ATP affinity and show energetic coupling.
bioRxiv · Mar 26, 2021Biophysics