Enterovirus A71 adaptation to heparan sulfate comes with capsid stability tradeoff
H. K. Tee, G. Mathez, V. Cagno, A. Antanasijevic, S. Clement, C. Tapparel
This study shows that EV-A71 adapts to heparan sulfate by losing pH-dependent uncoating, which compromises capsid stability and affects viral fitness in vivo.
bioRxiv · Feb 23, 2024Microbiology