Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A
K. N. Reisenauer, Y. Tao, S. Song, S. Patel, A. Ingros, P. Sheesley, M. Masi, A. Boari, J. H. Taube, A. Evidente, A. Kornienko, D. Romo
This study shows that breast cancer cells with EMT features are more sensitive to the cytotoxic effects of ophiobolin A, suggesting its potential as a targeted therapy.
bioRxiv · May 6, 2020Cancer Biology