S. Meyer

Resolving RH and GYP hybrid alleles while accessing the entire blood group genome with Nanopore adaptive sampling

This study evaluates adaptive sampling for resolving complex blood group variants using long-read sequencing, identifying novel alleles and hybrid haplotypes in RH and MNS systems.

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

This study shows BMP2 and BMP7 work with H3.3K27M to create a quiescent yet invasive state in pediatric gliomas.

FAM104 proteins promote the nuclear localization of p97/VCP

This study identifies FAM104 proteins as novel p97 interactors that facilitate nuclear import and chromatin binding of p97, highlighting their role in cellular processes and disease.

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

This study shows ADAMTSL1 is involved in skeletal muscle regeneration and acts as a prognostic factor in aggressive rhabdomyosarcoma, correlating with a neural-like phenotype.

ReSurveyGermany: Vegetation-plot time-series over the past hundred years in Germany

The paper compiles and harmonizes vegetation-plot resurvey data from Germany over almost 100 years, enabling analysis of biodiversity change and species distribution shifts.

Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.

Protein interaction network analysis reveals growth conditions-specific crosstalk between chromosomal DNA replication and other cellular processes in E. coli

The paper analyzes protein interaction networks in E. coli under different growth conditions to reveal crosstalk between DNA replication and other cellular processes.

Beyond Spike: Identification of nine highly prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a large Norwegian cohort

The paper identifies nine prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a Norwegian cohort, showing strong correlation between immunoprevalence and immunodominance.

Emergence of NADP+-reducing enzymes in Escherichia coli central metabolism via adaptive evolution

This study shows that adaptive evolution in E. coli can change cofactor specificity of enzymes, enabling NADPH regeneration without external sources, but is limited by thermodynamic constraints.

The discriminator sequence is a primary determinant in the supercoiling response of bacterial promoters

The paper identifies the discriminator sequence as a key determinant of bacterial promoter supercoiling response, validated through in vitro, in vivo, and evolutionary analyses.

Mapping the complex transcriptional landscape of the phytopathogenic bacterium Dickeya dadantii

This study maps the transcriptional landscape of Dickeya dadantii using multiple transcriptomic datasets, revealing complex transcription units and regulatory features beyond traditional operons.

The nucleoid-associated protein IHF acts as a domainin protein coordinating the bacterial virulence traits with global transcription

This study shows that IHF coordinates bacterial virulence traits with global transcription by altering DNA topology and gene expression in Dickeya dadantii.

Development and validation of an HPLC method to quantify 2-Keto-3-deoxy-gluconate (KDG), a major metabolite in pectin and alginate degradation pathways

The paper develops and validates an HPLC method with fluorescence detection to quantify KDG, a metabolite from pectin and alginate degradation pathways.

In vivo imaging of swimming micromotors using hybrid high-frequency ultrasound and photoacoustic imaging

This paper develops a hybrid imaging system combining high-frequency ultrasound and photoacoustic imaging to track magnetically driven micromotors in vivo and ex vivo.

Selective Plane Illumination Microscopy and Computing Reveal Differential Obliteration of Retinal Vascular Plexuses

The paper uses 3-D imaging and computational analysis to show preferential obliteration of retinal secondary plexuses in hyperoxia-induced retinopathy.

Spatio-temporal analysis at landscape scale of the Iberian oak decline epidemic caused by Phytophthora cinnamomi

The paper analyzes the spatio-temporal spread of Iberian oak decline caused by Phytophthora cinnamomi using aerial imagery and a spatio-temporal model, finding key patterns in infection spread and risk factors.

Plant traits are poor predictors of long-term ecosystem functioning

This study shows that plant traits poorly predict long-term ecosystem functioning, with only moderate explanatory power across years.

Phylogeny, morphology and the role of hybridization as driving force of evolution in grass tribes Aveneae and Poeae (Poaceae)

This study investigates the evolutionary diversification and morphological evolution of grass tribes Aveneae and Poeae by analyzing molecular phylogenetics and morphological traits, revealing hybridization as a key driver of speciation.

The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination.

The paper shows that the fungal compound pyrenophoric acid B inhibits seed germination by using the plant ABA biosynthetic pathway, not by activating ABA receptors.

Bacterial genome architecture shapes global transcriptional regulation by DNA supercoiling

The paper models how DNA supercoiling affects transcription in bacteria and shows that global gene orientation influences supercoiling sensitivity.

Characterizing The Structure-Function Relationship Of A Naturally-Occurring RNA Thermometer

The paper characterizes how an RNA thermometer in Salmonella enterica regulates gene expression through structural changes induced by temperature and ribosome binding.

Quantifying climate change impacts emphasises the importance of managing regional threats in the endangered Yellow-eyed penguin

The paper quantifies climate change impacts on Yellow-eyed penguin populations, finding sea surface temperature explains 33% of population variation, but highlights the need to address non-climatic threats.