Estrogen-related receptor beta activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma
D. M. Tiek, S. A. Khatib, C. J. Trepicchio, M. M. Heckler, S. D. Divekar, J. N. Sarkaria, E. Glasgow, R. B. Riggins
This study shows that ERRβ2 isoform expression, increased by CLK inhibition and ERRβ agonists, reduces GBM cell migration and tumor growth.
bioRxiv · Apr 25, 2019Cancer Biology