J. N. Sarkaria

This paper develops a physics-based cell migration simulator to identify physical biomarkers for glioblastoma, linking mechanical parameters to transcriptomic data and drug response.

This study shows CHCHD2 promotes glioblastoma cell proliferation, hypoxia-induced invasion, and drug resistance by affecting mitochondrial function and nuclear signaling.

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

This study shows mesenchymal glioblastoma cells migrate faster and generate more traction force than proneural cells, but their immunologically hot environment improves survival despite aggressive growth.

This study develops an engineered brain perivascular niche model to investigate how pericytes and astrocytes influence GBM tumor cell invasion, proliferation, and therapeutic response.

This paper uses mathematical modeling to differentiate between drug insensitivity and poor drug delivery in glioblastoma PDX models, validated by experimental results.

This study identifies a Syx-RhoA-Dia1-YAP/TAZ signaling axis that promotes glioblastoma growth, DNA damage, and therapy resistance, suggesting it as a therapeutic target.

This study evaluates the efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant gliomas, finding no significant effect on tumor growth or survival.

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

The paper develops a mathematical model to quantify glioblastoma drug response dynamics, finding that BBB permeability may slightly outweigh drug resistance in therapeutic efficacy.

This study uses a 3D hydrogel platform to investigate how extracellular matrix signals affect erlotinib efficacy in patient-derived glioblastoma cells with different EGFR mutations.

This study shows that ERRβ2 isoform expression, increased by CLK inhibition and ERRβ agonists, reduces GBM cell migration and tumor growth.

The paper uses image-based metrics to predict TMZ response in GBM patients, finding that less invasive tumors show greater volumetric response and improved survival.

This study investigates how different molecular weights of hyaluronic acid in hydrogels affect the invasive behavior of glioblastoma cells.

This study shows that H3K27me3 silencing of WT1 supports DIPG cell proliferation, despite global H3K27me3 loss due to H3.3K27M mutation.