Author

D. M. Tiek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

R. B. Riggins· 3 shared B. R. Haddad· 2 shared A. Goenka· 1 shared B. Erdogdu· 1 shared B. Hu· 1 shared C. Alamillo-Ferrer· 1 shared C. I. Wells· 1 shared C. J. Trepicchio· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

R. B. Riggins

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3 papers

Recent·Most cited

Cancer BiologybioRxivNov 21, 2021

Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug resistant gliomas

D. M. Tiek, B. Erdogdu, R. Razaghi…·R. B. Riggins

This study identifies guanine mutations in TMZ-resistant gliomas that disrupt G4 structures and splice sites, creating vulnerabilities targeted by G4 stabilizers and splicing inhibitors.

DOI 10.1126/sciadv.abn3471

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivApr 25, 2019

Estrogen-related receptor beta activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma

D. M. Tiek, S. A. Khatib, C. J. Trepicchio…·R. B. Riggins

This study shows that ERRβ2 isoform expression, increased by CLK inhibition and ERRβ agonists, reduces GBM cell migration and tumor growth.

DOI 10.1096/fj.201901075r

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivDec 14, 2017

Alterations in Cell Motility, Proliferation, and Metabolism in Novel Models of Acquired Temozolomide Resistant Glioblastoma

D. M. Tiek, J. D. Rone, G. T. Graham…·R. B. Riggins

This study creates and characterizes two new TMZ-resistant GBM cell lines, revealing distinct phenotypic changes associated with resistance.

DOI 10.1038/s41598-018-25588-1

humanbulk RNA-seq

𝕏 PostBluesky