Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity.
J. W. Smyth, S. Guo, L. O'Rourke, S. Deaver, J. Dahlka, E. Nurmemmedov, Z. Sheng, R. G. Gourdie, S. Lamouille
This study identifies a novel peptide, JM2, that disrupts Cx43-microtubule interaction in GBM stem-like cells, reducing their survival and tumorigenicity.
bioRxiv · Jan 26, 2024 · PreprintCancer Biology