Reactive Dicarbonyl Scavenging Effectively Reduces MPO-Mediated Oxidation of HDL and Preserves HDL Atheroprotective Functions
J. Huang, P. G. Yancey, H. Tao, M. Borja, S. E. Loren, V. Kon, S. S. Davies, M. F. Linton
This study shows that reactive dicarbonyl scavengers reduce MPO-mediated HDL oxidation, preserve HDL function, and improve cholesterol efflux in FH-HDL and mice.
bioRxiv · Jan 23, 2019Pharmacology & Toxicology